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Aborted Autophagy and Nonapoptotic Death Induced by Farnesyl Transferase Inhibitor and Lovastatin

Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-14, and NF90-8 to nanomolar concentrations of both lovastatin and farnesyl transferase inhibitor (FTI)-1 but not to either drug alone induced cell death. ST88-14 and NF90-8 cells underwent apoptosis, yet dying STS...

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Bibliografiske detaljer
Main Authors: Wojtkowiak, Jonathan W., Sane, Komal M., Kleinman, Miriam, Sloane, Bonnie F., Reiners, John J., Mattingly, Raymond R.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063739/
https://ncbi.nlm.nih.gov/pubmed/21228063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.174573
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