Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase

In overdose the analgesic/antipyretic acetaminophen (APAP) is hepatotoxic. Toxicity is mediated by initial hepatic metabolism to N-acetyl-p-benzoquinone imine (NAPQI). After low doses NAPQI is efficiently detoxified by GSH. However, in overdose GSH is depleted, NAPQI covalently binds to proteins as...

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Hlavní autoři: Agarwal, Rakhee, MacMillan-Crow, Lee Ann, Rafferty, Tonya M., Saba, Hamida, Roberts, Dean W., Fifer, E. Kim, James, Laura P., Hinson, Jack A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
Témata:
Toxicology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063736/
https://ncbi.nlm.nih.gov/pubmed/21205919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.176321
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