Increased Nicotinic Acetylcholine Receptor Protein Underlies Chronic Nicotine-Induced Up-Regulation of Nicotinic Agonist Binding Sites in Mouse Brain

Chronic nicotine treatment elicits a brain region-selective increase in the number of high-affinity agonist binding sites, a phenomenon termed up-regulation. Nicotine-induced up-regulation of α4β2-nicotinic acetylcholine receptors (nAChRs) in cell cultures results from increased assembly and/or decr...

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Главные авторы: Marks, Michael J., McClure-Begley, Tristan D., Whiteaker, Paul, Salminen, Outi, Brown, Robert W. B., Cooper, John, Collins, Allan C., Lindstrom, Jon M.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2011
Предметы:
Neuropharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063733/
https://ncbi.nlm.nih.gov/pubmed/21228066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.178236
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