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Fidelity escape by the unnatural amino acid β-hydroxynorvaline: an efficient substrate for Escherichia coli threonyl-tRNA synthetase with toxic effects on growth

In all living systems, the fidelity of translation is maintained in part by the editing mechanisms of aminoacyl-tRNA synthetases (ARSs). Some non-proteogenic amino acids, including β-hydroxynorvaline (HNV) are nevertheless efficiently aminoacylated and become incorporated into proteins. To investiga...

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Main Authors: Minajigi, Anand, Deng, Bin, Francklyn, Christopher S.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063515/
https://ncbi.nlm.nih.gov/pubmed/21222438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101360a
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