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Phosphatidylserine is a critical modulator for Akt activation
Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). The extent of insulin-like growth factor–induced Akt activation and downstrea...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063130/ https://ncbi.nlm.nih.gov/pubmed/21402788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201005100 |
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