Thyroid Hormone Receptor α and Regulation of Type 3 Deiodinase

Mice deficient in thyroid hormone receptor α (TRα) display hypersensitivity to thyroid hormone (TH), with normal serum TSH but diminished serum T(4). Our aim was to determine whether altered TH metabolism played a role in this hypersensitivity. TRα knockout (KO) mice have lower levels of rT(3), and...

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Autors principals: Barca-Mayo, Olga, Liao, Xiao-Hui, Alonso, Manuela, Di Cosmo, Caterina, Hernandez, Arturo, Refetoff, Samuel, Weiss, Roy E.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2011
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063087/
https://ncbi.nlm.nih.gov/pubmed/21292823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0213
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