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Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

BACKGROUND: The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Sign...

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Detalhes bibliográficos
Main Authors: Gu, Lili, Tsuji, Takahiro, Jarboui, Mohamed Ali, Yeo, Geok P, Sheehy, Noreen, Hall, William W, Gautier, Virginie W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062594/
https://ncbi.nlm.nih.gov/pubmed/21401918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-17
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