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Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity

The primary function of the HIV-1 regulatory protein Tat, activation of transcription from the viral LTR, is highly regulated by complex interactions between Tat and a number of host cell proteins. Tat nuclear import, a process mediated by importin β, is a prerequisite for its activity. Here, we rep...

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Detalhes bibliográficos
Main Authors: Gautier, Virginie W., Sheehy, Noreen, Duffy, Margaret, Hashimoto, Kenichi, Hall, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1275596/
https://ncbi.nlm.nih.gov/pubmed/16260749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503519102
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