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Incorporation of 5-bromodeoxycytidine in the adenovirus 2 replication origin interferes with nuclear factor 1 binding.

We have studied the binding of nuclear factor 1 (NFI), a human sequence-specific DNA-binding protein, to a DNA fragment substituted in vitro with 5-bromodeoxycytidine (5-BrdC). Even at low substitution grades binding of NFI to its recognition sequence was considerably lower than with the unsubstitut...

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Publicado no:Nucleic Acids Res
Principais autores: de Vries, E, Bloemers, S M, van der Vliet, P C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1987
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306244/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3658692/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/15.18.7223
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