Incorporation of 5-bromodeoxycytidine in the adenovirus 2 replication origin interferes with nuclear factor 1 binding.

We have studied the binding of nuclear factor 1 (NFI), a human sequence-specific DNA-binding protein, to a DNA fragment substituted in vitro with 5-bromodeoxycytidine (5-BrdC). Even at low substitution grades binding of NFI to its recognition sequence was considerably lower than with the unsubstitut...

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Hlavní autoři: de Vries, E, Bloemers, S M, van der Vliet, P C
Médium: Artigo
Jazyk:Inglês
Vydáno: 1987
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC306244/
https://ncbi.nlm.nih.gov/pubmed/3658692
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