Mechanism of inhibition of adenovirus DNA replication by the acyclic nucleoside triphosphate analogue (S)-HPMPApp: influence of the adenovirus DNA binding protein.

The acyclic adenosine analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [S]-HPMPA) is a potent and selective inhibitor of adenovirus (Ad) replication in cell culture. We studied the mechanism of inhibition using a reconstituted in vitro DNA replication system. The diphosphoryl derivative (...

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Hlavní autoři: Mul, Y M, van Miltenburg, R T, De Clercq, E, van der Vliet, P C
Médium: Artigo
Jazyk:Inglês
Vydáno: 1989
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC335103/
https://ncbi.nlm.nih.gov/pubmed/2587248
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