Mechanism of inhibition of adenovirus DNA replication by the acyclic nucleoside triphosphate analogue (S)-HPMPApp: influence of the adenovirus DNA binding protein.

The acyclic adenosine analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [S]-HPMPA) is a potent and selective inhibitor of adenovirus (Ad) replication in cell culture. We studied the mechanism of inhibition using a reconstituted in vitro DNA replication system. The diphosphoryl derivative (...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mul, Y M, van Miltenburg, R T, De Clercq, E, van der Vliet, P C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1989
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC335103/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2587248/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.22.8917
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