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Effector analogues detect varied allosteric roles for conserved protein-effector interactions in pyruvate kinase isozymes
The binding site for allosteric inhibitor (amino acid) is highly conserved between human liver pyruvate kinase (hL-PYK) and the rabbit muscle isozyme (rM(1)-PYK). To detail similarities/differences in the allosteric function of these two homologs, we quantified the binding of 45 amino acid analogues...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062439/ https://ncbi.nlm.nih.gov/pubmed/21261284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200052e |
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