Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

The transcription factor PU.1 occupies a central role in controlling myeloid and early B-cell development, and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established....

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Main Authors: Leddin, Mathias, Perrod, Chiara, Hoogenkamp, Maarten, Ghani, Saeed, Assi, Salam, Heinz, Sven, Wilson, Nicola K., Follows, George, Schönheit, Jörg, Vockentanz, Lena, Mosammam, Ali M., Chen, Wei, Tenen, Daniel G., Westhead, David R., Göttgens, Berthold, Bonifer, Constanze, Rosenbauer, Frank
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062295/
https://ncbi.nlm.nih.gov/pubmed/21239694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-302976
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