Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression

Eukaryotic cells license far more origins than are actually used for DNA replication, thereby generating a large number of dormant origins. Accumulating evidence suggests that such origins play a role in chromosome stability and tumor suppression, though the underlying mechanism is largely unknown....

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Bibliographische Detailangaben
Hauptverfasser: Kawabata, Tsuyoshi, Luebben, Spencer W., Yamaguchi, Satoru, Ilves, Ivar, Matise, Ilze, Buske, Tavanna, Botchan, Michael R., Shima, Naoko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062258/
https://ncbi.nlm.nih.gov/pubmed/21362550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.006
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