Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

Endoplasmic reticulum (ER) stress is a common factor in the pathophysiology of diverse human diseases that are characterised by contrasting cellular behaviours, from proliferation in cancer to apoptosis in neurodegenerative disorders. Coincidently, dysregulation of AKT/PKB activity, which is the cen...

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Bibliographische Detailangaben
Hauptverfasser: Yung, Hong Wa, Charnock-Jones, D. Stephen, Burton, Graham J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061875/
https://ncbi.nlm.nih.gov/pubmed/21445305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017894
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