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Strategies for the Identification of novel inhibitors of deubiquitinating enzymes
Dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in a wide range of pathologies including cancer, neurodegeneration, and viral infection. Inhibiting the proteasome has been shown to be an effective therapeutic strategy in humans; yet toxicity with this target remains high....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061546/ https://ncbi.nlm.nih.gov/pubmed/18793145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST0360828 |
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