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Strategies for the Identification of Ubiquitin Ligase Inhibitors
Dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in a wide range of pathologies including cancer, neurodegeneration, and viral infection. Inhibiting the proteasome has been shown to be an effective therapeutic strategy in humans; yet toxicity with this target remains high....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060714/ https://ncbi.nlm.nih.gov/pubmed/20074047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST0380132 |
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