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Strategies for the Identification of Ubiquitin Ligase Inhibitors

Dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in a wide range of pathologies including cancer, neurodegeneration, and viral infection. Inhibiting the proteasome has been shown to be an effective therapeutic strategy in humans; yet toxicity with this target remains high....

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Библиографические подробности
Главные авторы: Goldenberg, Seth J, Marblestone, Jeffrey G, Mattern, Michael R, Nicholson, Benjamin
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060714/
https://ncbi.nlm.nih.gov/pubmed/20074047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST0380132
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