A Substituted Anilino Enaminone Acts as a Novel Positive Allosteric Modulator of GABA(A) Receptors in the Mouse Brain

A small library of anilino enaminones was analyzed for potential anticonvulsant agents. We examined the effects of three anilino enaminones on neuronal activity of output neurons, mitral cells (MC), in an olfactory bulb brain slice preparation using whole-cell patch-clamp recording. These compounds...

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Bibliographic Details
Main Authors: Wang, Ze-Jun, Sun, Liqin, Jackson, Patrice L., Scott, Kenneth R., Heinbockel, Thomas
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061544/
https://ncbi.nlm.nih.gov/pubmed/21163867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.173740
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