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Effect of Phospholipidosis on the Cellular Pharmacokinetics of Chloroquine

In vivo, the weakly basic, lipophilic drug chloroquine (CQ) accumulates in the kidney to concentrations more than a thousand-fold greater than those in plasma. To study the cellular pharmacokinetics of chloroquine in cells derived from the distal tubule, Madin-Darby canine kidney cells were incubate...

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Bibliografski detalji
Glavni autori: Zheng, Nan, Zhang, Xinyuan, Rosania, Gus R.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061524/
https://ncbi.nlm.nih.gov/pubmed/21156819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175679
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