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A CELL-BASED MOLECULAR TRANSPORT SIMULATOR FOR PHARMACOKINETIC PREDICTION AND CHEMINFORMATIC EXPLORATION

In the body, cell monolayers serve as permeability barriers, determining transport of drug molecules from one organ or tissue compartment to another. After oral administration, for example, drug transport across the epithelial cell monolayer lining the lumen of the intestine determines the fraction...

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Detalhes bibliográficos
Main Authors: Zhang, Xinyuan, Shedden, Kerby, Rosania, Gus R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710883/
https://ncbi.nlm.nih.gov/pubmed/17140258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp060046k
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