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Effect of Phospholipidosis on the Cellular Pharmacokinetics of Chloroquine
In vivo, the weakly basic, lipophilic drug chloroquine (CQ) accumulates in the kidney to concentrations more than a thousand-fold greater than those in plasma. To study the cellular pharmacokinetics of chloroquine in cells derived from the distal tubule, Madin-Darby canine kidney cells were incubate...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061524/ https://ncbi.nlm.nih.gov/pubmed/21156819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175679 |
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