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Genetic variation in the TGF-β-signaling pathway and colon and rectal cancer risk

BACKGROUND: The TGF-β-signaling pathway is an essential regulator of many cellular process involved in carcinogenesis. Smad proteins are central to the function of TGF-β-signaling. In this study we evaluate genetic variation in TGFβ1, TGFβR1, Smad1, Smad2, Smad3, and Smad4 and risk of colon and rect...

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Hlavní autoři: Slattery, Martha L., Herrick, Jennifer S., Lundgreen, Abbie, Wolff, Roger K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061458/
https://ncbi.nlm.nih.gov/pubmed/21068203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-10-0843
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