Beneficial Effects of Adenylyl Cyclase Type 6 (AC6) Expression Persist Using a Catalytically Inactive AC6 Mutant

Cardiac-directed expression of AC6 has pronounced favorable effects on cardiac function possibly not linked with cAMP production. To determine rigorously whether cAMP generation is required for the beneficial effects of increased AC6 expression, we generated a catalytically inactive AC6 mutant (AC6m...

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Huvudupphovsmän: Gao, Mei Hua, Tang, Tong, Lai, Ngai Chin, Miyanohara, Atsushi, Guo, Tracy, Tang, Rouying, Firth, Amy L., Yuan, Jason X., Hammond, H. Kirk
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061356/
https://ncbi.nlm.nih.gov/pubmed/21127130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067298
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