Comparison of Methods for the Purification of Alpha-1 Acid Glycoprotein from Human Plasma

Eitemau Tebyg

• In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall
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• Addition of a sequence from α(2)-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis
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• Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2
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• A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss
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  Cyhoeddwyd: (2018)