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Addition of a sequence from α(2)-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis

BACKGROUND: The plasma protein α(2)-antiplasmin (α(2)AP) is cross-linked to fibrin in blood clots by the transglutaminase factor XIIIa, and in that location retards clot lysis. Competition for this effect could be clinically useful in patients with thrombosis. We hypothesized that fusion of N-termin...

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Détails bibliographiques
Auteurs principaux: Sheffield, William P, Eltringham-Smith, Louise J, Gataiance, Sharon, Bhakta, Varsha
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654442/
https://ncbi.nlm.nih.gov/pubmed/19257897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-9-15
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