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Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA
We report the synthesis of two C4′-modified DNA analogues and characterize their structural impact on dsDNA duplexes. The 4′-C-piperazinomethyl modification stabilizes dsDNA by up to 5°C per incorporation. Extension of the modification with a butanoyl-linked pyrene increases the dsDNA stabilization...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061067/ https://ncbi.nlm.nih.gov/pubmed/21062815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1123 |
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