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Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface

Transcription mediated by hypoxia-inducible factor (HIF-1) contributes to tumor angiogenesis and metastasis but is also involved in activation of cell-death pathways and normal physiological processes. Given the complexity of HIF-1 signaling, it could be advantageous to target a subset of HIF-1 effe...

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Autors principals: Nickols, Nicholas G., Jacobs, Claire S., Farkas, Michelle E., Dervan, Peter B.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060759/
https://ncbi.nlm.nih.gov/pubmed/17708671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb700110z
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