KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation

The goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1 receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious puberty. Confocal imaging showed colocalization of wild-type (WT) KISS1R with a membrane marker, which persisted for up to 5 h...

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Detalhes bibliográficos
Main Authors: Bianco, Suzy D. C., Vandepas, Lauren, Correa-Medina, Mayrin, Gereben, Balázs, Mukherjee, Abir, Kuohung, Wendy, Carroll, Rona, Teles, Milena G., Latronico, Ana Claudia, Kaiser, Ursula B.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Reproduction-Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060635/
https://ncbi.nlm.nih.gov/pubmed/21285314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0903
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