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Atomic-level characterization of the ensemble of the Aβ(1-42) monomer in water using unbiased Molecular Dynamics simulations and spectral algorithms
Aβ(1-42) is the highly pathologic isoform of amyloid-β, the peptide constituent of fibrils and neurotoxic oligomers involved in Alzheimer’s disease. Recent studies on the structural features of Aβ in water have suggested that the system can be described as an ensemble of distinct conformational spec...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060569/ https://ncbi.nlm.nih.gov/pubmed/21056574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.015 |
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