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The Alzheimer’s peptides Aβ40 and 42 adopt distinct conformations in water: A combined MD / NMR study.
The role of two peptides, Aβ40 and Aβ42 in the early pathogenesis of the Alzheimer's disease (AD) is frequently emphasized in the literature. It is known that Aβ42 is more prone to aggregation than Aβ40, even though they only differ in two (IA) amino acid residues at the C-terminal end. A direc...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1978067/ https://ncbi.nlm.nih.gov/pubmed/17397862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.093 |
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