Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation

The double-stranded RNA analog, poly(I:C), extracellularly activates both the endosomal Toll-like receptor (TLR) 3 and the cytoplasmic RNA helicase, melanoma differentiation-associated gene 5, leading to the production of type I interferons (IFNs) and inflammatory cytokines. The mechanism by which e...

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Bibliographische Detailangaben
Hauptverfasser: Watanabe, Ayako, Tatematsu, Megumi, Saeki, Kazuko, Shibata, Sachiko, Shime, Hiroaki, Yoshimura, Akihiko, Obuse, Chikashi, Seya, Tsukasa, Matsumoto, Misako
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060521/
https://ncbi.nlm.nih.gov/pubmed/21266579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185793
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