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hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

DNA damage response (DDR) activates a complex signaling network that triggers DNA repair, cell cycle arrest, and/or cell death. Depending on the type and severity of DNA lesion, DDR is controlled by “master” regulators including ATM and ATR protein kinases. Cisplatin, a major chemotherapy drug that...

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Detalhes bibliográficos
Main Authors: Pabla, Navjotsingh, Ma, Zhengwei, McIlhatton, Michael A., Fishel, Richard, Dong, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060494/
https://ncbi.nlm.nih.gov/pubmed/21285353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210989
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