Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a

The sarcoplasmic reticulum calcium ATPase (SERCA) plays a central role in regulating intracellular Ca(2+) homeostasis and myocardial contractility. Several studies show that improving Ca(2+) handling in hypertrophied rodent hearts by increasing SERCA activity results in enhanced contractile function...

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Hlavní autoři: Pinz, Ilka, Tian, Rong, Belke, Darrell, Swanson, Eric, Dillmann, Wolfgang, Ingwall, Joanne S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Bioenergetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060468/
https://ncbi.nlm.nih.gov/pubmed/21278384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210757
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