Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells

Although alternative DNA secondary structures (non-B DNA) can induce genomic rearrangements, their associated mutational spectra remain largely unknown. The helicase activity of WRN, which is absent in the human progeroid Werner syndrome, is thought to counteract this genomic instability. We determi...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bacolla, Albino, Wang, Guliang, Jain, Aklank, Chuzhanova, Nadia A., Cer, Regina Z., Collins, Jack R., Cooper, David N., Bohr, Vilhelm A., Vasquez, Karen M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060453/
https://ncbi.nlm.nih.gov/pubmed/21285356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176636
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires