Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells

Although alternative DNA secondary structures (non-B DNA) can induce genomic rearrangements, their associated mutational spectra remain largely unknown. The helicase activity of WRN, which is absent in the human progeroid Werner syndrome, is thought to counteract this genomic instability. We determi...

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Detalhes bibliográficos
Main Authors: Bacolla, Albino, Wang, Guliang, Jain, Aklank, Chuzhanova, Nadia A., Cer, Regina Z., Collins, Jack R., Cooper, David N., Bohr, Vilhelm A., Vasquez, Karen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060453/
https://ncbi.nlm.nih.gov/pubmed/21285356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176636
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