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Initial FGF23-Mediated Signaling Occurs in the Distal Convoluted Tubule

Fibroblast growth factor-23 (FGF23), a hormone central to phosphate and vitamin D metabolism, reduces renal absorption of phosphate by downregulating the sodium-phosphate cotransporter Npt2a. However, the mechanisms of FGF23 action in the kidney are unclear, as Npt2a localizes to the proximal tubule...

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Detalhes bibliográficos
Main Authors: Farrow, Emily G., Davis, Siobhan I., Summers, Lelia J., White, Kenneth E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060419/
https://ncbi.nlm.nih.gov/pubmed/19357251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008070783
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