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Altered Renal FGF23-Mediated Activity Involving MAPK and Wnt: Effects of the Hyp Mutation

Fibroblast growth factor-23 (FGF23), a hormone central to renal phosphate handling, is elevated in multiple hypophosphatemic disorders. Initial FGF23-dependent Erk1/2 activity in the kidney localizes to the distal convoluted tubule (DCT) with the co-receptor α-Klotho (KL), distinct from Npt2a in pro...

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Detalhes bibliográficos
Main Authors: Farrow, Emily G., Summers, Lelia J., Schiavi, Susan C., McCormick, James A., Ellison, David H., White, Kenneth E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050595/
https://ncbi.nlm.nih.gov/pubmed/20675303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-10-0181
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