A Chloroacetamidine-based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and in Vitro and in Vivo Evaluation

Protein arginine methyltransferases (PRMTs) catalyze the post-translational methylation of arginine residues. PRMT1 is the predominant mammalian isozyme, and is responsible for generating the majority of the asymmetrically dimethylated arginine found in vivo. The dysregulation of this enzyme has bee...

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Bibliographic Details
Main Authors: Obianyo, Obiamaka, Causey, Corey P., Osborne, Tanesha, Jones, Justin E., Lee, Young-Ho, Stallcup, Michael R., Thompson, Paul R.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060404/
https://ncbi.nlm.nih.gov/pubmed/20480486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000209
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