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Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling
Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes impli...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059912/ https://ncbi.nlm.nih.gov/pubmed/21293490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.210 |
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