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Turnover of Amyloid Precursor Protein Family Members Determines Their Nuclear Signaling Capability
The amyloid precursor protein (APP) as well as its homologues, APP-like protein 1 and 2 (APLP1 and APLP2), are cleaved by α-, β-, and γ-secretases, resulting in the release of their intracellular domains (ICDs). We have shown that the APP intracellular domain (AICD) is transported to the nucleus by...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3715505/ https://ncbi.nlm.nih.gov/pubmed/23874953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069363 |
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