CARMA3 is crucial for EGFR-induced activation of NF-κB and tumor progression

EGF activates NF-κB and constitutively activated NF-κB contributes to EGFR mutation-associated tumorigenesis, but it remains unclear precisely how EGFR signaling leads to NF-κB activation. Here we report that CARMA3, a Caspase Recruitment Domain (CARD)-containing scaffold molecule, is required for E...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jiang, Tang, Grabiner, Brian, Zhu, Yifan, Jiang, Changying, Li, Hongxiu, You, Yun, Lang, Jingyu, Hung, Mien-Chie, Lin, Xin
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059846/
https://ncbi.nlm.nih.gov/pubmed/21406399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3626
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