Cyclin D2 and the CDK Substrate p220(NPAT) are Required for Self-Renewal of Human Embryonic Stem Cells

Self-renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB dependent growth control. We investigated whether self-renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220(NPAT)/HiNF-P complex to activate histone gene expr...

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Autores principales: Becker, Klaus A., Ghule, Prachi N., Lian, Jane B., Stein, Janet L., van Wijnen, Andre J., Stein, Gary S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059841/
https://ncbi.nlm.nih.gov/pubmed/19890848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21967
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