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Cyclin D2 and the CDK Substrate p220(NPAT) are Required for Self-Renewal of Human Embryonic Stem Cells
Self-renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB dependent growth control. We investigated whether self-renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220(NPAT)/HiNF-P complex to activate histone gene expr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059841/ https://ncbi.nlm.nih.gov/pubmed/19890848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21967 |
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