A Ca(2+)-Based Computational Model for NMDA Receptor-Dependent Synaptic Plasticity at Individual Post-Synaptic Spines in the Hippocampus

Associative synaptic plasticity is synapse specific and requires coincident activity in pre-synaptic and post-synaptic neurons to activate NMDA receptors (NMDARs). The resultant Ca(2+) influx is the critical trigger for the induction of synaptic plasticity. Given its centrality for the induction of...

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Главные авторы: Rackham, Owen J. L., Tsaneva-Atanasova, Krasimira, Ganesh, Ayalvadi, Mellor, Jack R.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Research Foundation 2010
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059685/
https://ncbi.nlm.nih.gov/pubmed/21423517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsyn.2010.00031
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