FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism

PURPOSE: Anti-angiogenic therapies can be an important adjunct to the management of many malignancies. Here we investigated a novel protein, FKBPL, and peptide derivative for their anti-angiogenic activity and mechanism of action. EXPERIMENTAL DESIGN: Recombinant FKBPL (rFKBPL) and its peptide deriv...

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Hauptverfasser: Valentine, Andrea, O’Rourke, Martin, Yakkundi, Anita, Worthington, Jenny, Hookham, Michelle, Bicknell, Roy, McCarthy, Helen O., McClelland, Keeva, McCallum, Lynn, Dyer, Hayder, McKeen, Hayley, Waugh, David, Roberts, Jennifer, McGregor, Joanne, Cotton, Graham, James, Iain, Harrison, Timothy, Hirst, David G., Robson, Tracy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059488/
https://ncbi.nlm.nih.gov/pubmed/21364036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2241
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