Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers

The thiopurines, 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used in the treatment of leukaemia. Incorporation of deoxythioguanosine nucleotides (dG(s)) into the DNA of thiopurine-treated cells causes cell death but there is also evidence that thiopurine metabolites, particularly the 6-MP m...

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Bibliografiset tiedot
Päätekijät: Coulthard, Sally A., Redfern, Christopher P.F., Vikingsson, Svante, Appell, Malin Lindqvist, Skoglund, Karin, Falk, Ingrid Jakobsen, Hall, Andrew G., Taylor, Gordon A., Hogarth, Linda A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059482/
https://ncbi.nlm.nih.gov/pubmed/21282358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0798
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