Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long term TβRI/II kinase inhibition with LY2109761

Transforming Growth Factor β (TGF-β) is produced excessively by many solid tumors and can drive malignant progression through multiple effects on the tumor cell and microenvironment. TGF-β signaling pathway inhibitors have shown efficacy in pre-clinical models of metastatic cancer. Here we investiga...

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Detalhes bibliográficos
Main Authors: Connolly, Erin C., Saunier, Elise F., Quigley, David, Luu, Minh Thu, Sapio, Angela De, Hann, Byron, Yingling, Jonathan M., Akhurst, Rosemary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059399/
https://ncbi.nlm.nih.gov/pubmed/21282335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2941
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