Cytoplasmic Domain of P-selectin Glycoprotein Ligand-1 Facilitates Dimerization and Export from the Endoplasmic Reticulum

P-selectin glycoprotein ligand-1 (PSGL-1) is a homodimeric transmembrane mucin on leukocytes. During inflammation, reversible interactions of PSGL-1 with selectins mediate leukocyte rolling on vascular surfaces. The transmembrane domain of PSGL-1 is required for dimerization, and the cytoplasmic dom...

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Autors principals: Miner, Jonathan J., Shao, Bojing, Wang, Ying, Chichili, Gurunadh R., Liu, Zhenghui, Klopocki, Arkadiusz G., Yago, Tadayuki, McDaniel, J. Michael, Rodgers, William, Xia, Lijun, McEver, Rodger P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059044/
https://ncbi.nlm.nih.gov/pubmed/21220419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208777
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