Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins

Inducible nitric-oxide synthase (iNOS, NOS2) plays a prominent role in macrophage bactericidal and tumoricidal activities. A relatively large amount of NO produced via iNOS, however, also targets the macrophage itself for apoptotic cell death. To uncover the intrinsic mechanisms of iNOS regulation,...

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Bibliographic Details
Main Authors: Nishiya, Tadashi, Matsumoto, Kazuma, Maekawa, Satoshi, Kajita, Emi, Horinouchi, Takahiro, Fujimuro, Masahiro, Ogasawara, Kouetsu, Uehara, Takashi, Miwa, Soichi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058989/
https://ncbi.nlm.nih.gov/pubmed/21199876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190678
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