Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

Dyshomeostasis of extracellular zinc and copper has been implicated in β-amyloid aggregation, the major pathology associated with Alzheimer disease. Presenilin mediates the proteolytic cleavage of the β-amyloid precursor protein to release β-amyloid, and mutations in presenilin can cause familial Al...

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Bibliographic Details
Main Authors: Greenough, Mark A., Volitakis, Irene, Li, Qiao-Xin, Laughton, Katrina, Evin, Genevieve, Ho, Michael, Dalziel, Andrew H., Camakaris, James, Bush, Ashley I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058959/
https://ncbi.nlm.nih.gov/pubmed/21239495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163964
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