Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

Dyshomeostasis of extracellular zinc and copper has been implicated in β-amyloid aggregation, the major pathology associated with Alzheimer disease. Presenilin mediates the proteolytic cleavage of the β-amyloid precursor protein to release β-amyloid, and mutations in presenilin can cause familial Al...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Greenough, Mark A., Volitakis, Irene, Li, Qiao-Xin, Laughton, Katrina, Evin, Genevieve, Ho, Michael, Dalziel, Andrew H., Camakaris, James, Bush, Ashley I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058959/
https://ncbi.nlm.nih.gov/pubmed/21239495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163964
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak